N,N'-BIS(2-(3-SUBSTITUTED-4-HYDROXYPHENYL)-ETHYL OR -2-HYDROXYETHYL)-POLYMETHYLENEDIAMINES

摘要

Polymethylenediamines are disclosed of the formula: in which n is a positive whole integer of from 4 to 8; Y is NH2, NHCHO, NHCOCH3, NHCONH2, NHSO2R, NHCO2R, NHCONHR, NHSO2NH2, NHSO2N(CH3)2, CH2OH, CH2NH2, CH2NHSO2R, CH2NHCONH2 or CH2SO2R; and R is lower alkyl of from 1 to 5 carbon atoms, straight or branched chain. The compounds have .beta.-adrenergic stimulant activity particularly as selected bronchodilators and are prepared generally by condensation of an N-benzyl-phenethlamine with a polymethylene dihalide or by reaction of an .alpha.-bromoacetophenone with an N,N'-dibenzyl-polymethylene-diamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon.