| 摘要 |
<p>What is disclosed is a glycoprotein having proteolytic, fibrinolytic, and thrombolytic properties and which can be used to prepare anti-sera useful as diagnostic agents, said glycoprotein being found in human blood serum and extracts of human placentas and being capable of isolation therefrom and which has the following properties: a protein proportion essentially consisting of 89+/-4% of alpha -amino-acids, a carbohydrate proportion of 11.1+/-2.2%, among it 5.3+/-1.1% of hexoses, 2.8+/-0.5 N of N-acetylated hexosamine, 2.9+/-0.6% of N-acetylated neuraminic acid; a sedimentation coefficient S20x of 3.2+/-0.3 S; a molecular weight of 32 000+/-6 000; an iso-electric point at pH 4.3+/-0.3; an extinction coefficient E1 cm1% (280 nm) of 13.8+/-1.0; an electrophoretic mobility in the range between that of albumin and alpha 1-globulins; a specific immunologic reaction with an antibody specifically directed against the protein, and a proteolytic activity, as well as a process for isolating it.</p> |
