发明名称 |
DNA binding compound-mediated molecular switch system |
摘要 |
The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.
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申请公布号 |
US7189506(B1) |
申请公布日期 |
2007.03.13 |
申请号 |
US20000518297 |
申请日期 |
2000.03.03 |
申请人 |
GENELABS TECHNOLOGIES, INC. |
发明人 |
LIM MOON YOUNG;EDWARDS CYNTHIA A.;FRY KIRK E.;BRUICE THOMAS W.;STARR DOUGLAS B.;LAURANCE MEGAN E.;KWOK YAN;TAM ALBERT W. |
分类号 |
C12Q1/68;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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