| 摘要 |
<p>1534216 Mumps vaccine MEDICINSKA AKADAMIA 8 July 1977 28853/77 Heading A5B [Also in Division C6] Mumps vaccine containing attenuated live mumps virus is produced by attenuating Sofia 6 strain of mumps virus by serial passage on a cell culture of cells from the kidneys of newborn guinea pigs (suitably 12 to 25 passages), and then multiplying the attenuated virus by allowing it to replicate on a cell culture of kidney cells of newborn guinea pigs, the culture being infected when it is three to five days old, then collecting the virus, e.g. 2, 4 or 6 days after inoculation of the cell culture, and using it to form a vaccine. The collected virus may be lyophilised, optionally after addition of a stabiliser such as sucrose, human albumin, phosphate and/or gelatin.</p> |
