发明名称 |
PROCESS FOR PRODUCING NEW CEPHEME DERIVATIVES |
摘要 |
Novel cephem compounds having a group of the formula at the 3-position thereof: <IMAGE> wherein X represents oxygen, sulfur or imino, which may be substituted; and B represents hydrogen or a hydroxyl, amino, mercapto or hydrocarbon group, which groups may be substituted, can be prepared by reacting a 3-formylcephem compound with a hydrazine compound of the formula: <IMAGE> wherein the symbols have the same meanings as above, and subjecting the thus obtained compound to an oxidative ring-closure reaction. The objective compounds are found to have a broad antimicrobial spectrum and, in particular, are effective against gram-negative bacteria including Escherichia Coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus rettgerii, as well as gram positive ones, and have low-toxity. Thus, these compounds may be used for antimicrobial agents in therapeutical purpose. |
申请公布号 |
HU172729(B) |
申请公布日期 |
1978.11.28 |
申请号 |
HU1976TA01400 |
申请日期 |
1976.05.10 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES,LTD,JP |
发明人 |
MIKI,TAKUICHI,JP;MATSUO,TAISUKE,JP;SUGAWARA,TOHRU,JP;MASUYA,HIROMOTO,JP |
分类号 |
C07D501/14;A61K31/545;A61K31/546;A61P31/04;C07D;C07D501/00;C07D501/04;C07D501/06;C07D501/16;C07D501/18;C07D501/20;C07D501/24;C07D501/48;C07D501/57;C07D501/60 |
主分类号 |
C07D501/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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