摘要 |
<p>An alkylcarbamoyl naphthalenyloxy octenoyl hydroxyamide derivative, its pharmaceutically acceptable salt, a method for preparing the derivative, and an anticancer pharmaceutical composition containing the derivative or the salt are provided to inhibit the enzymatic activity of histone deacetylase effectively and to suppress the proliferation of tumor cells. An alkylcarbamoyl naphthalenyloxy octenoyl hydroxyamide derivative is represented by the formula 1, wherein R1 is a C1-C3 alkyl group substituted or unsubstituted with at least one substituent selected from the group consisting of a halophenyl group, a C1-C3 alkoxy C1-C3 alkyl group, a cyclohexanyl group, a furanyl group, a thiophenyl group, an imidazole group, an imidazolidyl C1-C3 alkyl group, a C1-C3 alkylamino group, a di-C1-C3 alkylamino group, a hydroxyphenyl group, a tetrahydrofuranyl group, a cyclohexyl group, a cyclohexenyl group, an oxopyrrolidinyl group, an alkoxyphenyl group, a di-C1-C3 alkylaminophenyl group, a C1-C3 alkylpyrrolidinyl group and a trifluoromethoxyphenyl group; a pyrrolidine group substituted or unsubstituted with at least one substituent selected from the group consisting of a C3-C8 cycloalkyl group, a C3-C8 cycloalkyl C1-C3 alkyl group, a benzyl group, a C1-C3 alkyl group or a C3-C8 cycloalkylcarbonyl group; a piperidine group substituted with a C1-C3 alkyl group or a C3-C8 cycloalkyl group; a furan group; or a C3-C8 cycloalkyl group.</p> |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;CRYSTALGENOMICS, INC. |
发明人 |
LEE, CHEOL HAE;JUNG, HEE JUNG;KIM, JAE HAK;JEONG, WON JANG;CHO, JOONG MYUNG;RO, SEONG GU;HYUN, YOUNG LAN;LEE, CHEOL SOON |