| 摘要 |
The invention concerns novel guanidine derivatives of the general formula (I) <IMAGE> (I) or pharmaceutically acceptable acid addition salts thereof, where &cir& Nrepresents <IMAGE> <IMAGE> wherein R1 and R2 each represent hydrogen, lower alkyl, trifluoromethyl or halogen and R11 and R12 each represent hydrogen, lower alkyl, trifluoromethyl or halogen with the proviso that when one or both R11 or R12 groups represent halogen then R1 and R2 each represent lower alkyl, trifluoromethyl or halogen, R9 and R10 each represent hydrogen, lower alkyl or trifluoromethyl and R13 and R14 each represent hydrogen, lower alkyl, trifuoromethyl or halogen with the proviso that when one or both R13 and R14 groups represent halogen then R9 and R10 each represent lower alkyl or trifluoromethyl and R7 and R8 each represent hydrogen or lower alkyl and R3, R4, R5 and R6 each represent hydrogen or lower alkyl or R4 and R6 are each hydrogen and R3 and R5 together represent dimethylene or trimethylene. The guanidine derivatives lower blood pressure in warm-blooded animals. |
