发明名称 |
7-Methoxycephalosporin derivatives |
摘要 |
A compound having the formula <IMAGE> wherein Y represents a 2-carboxyethylthio group or a trifluoromethylthio group and a nontoxic pharmaceutically acceptable salt thereof are useful as antibacterial agents. They may be prepared by (a) reacting a compound having the formula <IMAGE> wherein X1 represents a halogen atom with a compound having the formula Y - H wherein Y has the same meaning as defined above, or (b) reacting a compound having the formula <IMAGE> wherein R represents a protective group for the carboxyl group with a compound having the formula Y - CH2COX2 wherein X2 represents a halogen atom and Y has the same meaning as defined above and removing the protective group for the carboxyl group from the resulting product, or (c) reacting a compound having the formula <IMAGE> wherein A represents an acetoxy group or a carbamoyloxy group and Y has the same meaning as defined above with 5-mercapto-1-methyl-1H-tetrazole or its alkali metal salt.
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申请公布号 |
US4126745(A) |
申请公布日期 |
1978.11.21 |
申请号 |
US19760676488 |
申请日期 |
1976.04.13 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
NAKAO, HIDEO;YANAGISAWA, HIROAKI;SHIMIZU, BUNJI;KANEKO, MASAKATSU;NAGANO, MITSUO;SUGAWARA, SHINICHI |
分类号 |
A61K31/545;C07D;C07D205/08;C07D257/04;C07D279/04;C07D501/00;C07D501/36;C07D501/40;C07D501/50;C07D501/57;C07D501/60;(IPC1-7):C07D501/50;A61K31/54 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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