| 摘要 |
1413262 2-(Phenoxyalkyl-thio, -sulphinyl and sulphonyl)-imidazoles G D SEARLE & CO 21 Jan 1974 [22 Jan 1973] 02742/74 Heading C2C The invention comprises novel compounds (I) wherein R<SP>1</SP> is hydrogen or alkyl of 1 to 7 carbon atoms; R<SP>11</SP> is hydrogen or methyl; X<SP>1</SP> is hydrogen or nitro; Z is thio, sulfinyl, or sulfonyl; Alk is alkylene of 1 to 7 carbon atoms; and Ph is phenyl or a radical of the formula wherein X<SP>11</SP> represents 1 to 5 substituents, which can be alike or different, and which are selected from halogen, nitro, cyano, formyl, carboxy, alkyl of 1 to 7 carbon atoms, ethylenedioxymethyl, dialkoxymethyl wheeein the alkoxy portions each contain 1 to 7 carbon atoms, alkoxycarbonyl wherein the alkoxy portion contains 1 to 7 carbon atoms, and -COO-M<SP>+</SP> wherein M is an alkali metal, an alkaline-earth metal/2 or ammonium; and the non-toxic pharmaceutically acceptable acid addition salts thereof wherein Ph is other than -COO-M<SP>+</SP>- substituted-phenyl. They are made by standard methods. The following compounds are also prepared: 7 - bromoheptyl o - nitrophenyl ether, 1,7 - bis- (o - nitro - phenoxy)heptane, # - bromo - pcyanophenetole, 1,5 - bis(m - formylphenoxy)- 3 - methyl - pentane, 5 - bromo - 3 - methylpentyl m formylphenyl ether and p - (2 - bromoethoxy)- dimethoxymethylbenzene. Pharmaceutical preparations raving antigonococcal, antibacterial and antifungal actions contain (I) as active ingredient. Administration is orally, topically or parenterally. |
