| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention concerns medicine and pharmaceutical industry, particularly pelletised formulation of clopidogrel or its pharmaceutically acceptable salt with anti-aggregation or anti-thrombotic effect, including core containing clopidogrel or its pharmaceutically acceptable salt, starch, microcrystalline cellulose, propyleneglycol, alkali metal stearate and carrier, and film shell coating the core. Additionally the core includes hydrated castor oil in amount of 2-8 wt %, and shell also includes hydroxypropylmethylcellulose in amount of 2-2.5 wt % and propyleneglycol in amount of 0.55-0.60 wt % and does not include methylcellulose. Also invention concerns method of obtainment of the pelletised formulation and its application in prevention of thrombotic and atherothrombotic states accompanied by increased thrombocyte aggregation. ^ EFFECT: high physical and chemical storage stability, fast decomposition upon oral administration, simplified production technology at low cost. ^ 15 cl, 3 ex, 1 tbl |
