| 摘要 |
A method for producing a complementary, replica array from a master array of bio-molecules. The replica substrate is separated from the master array by a layer of liquid. The master array has master bio-molecules covalently attached to its confronting surface, and complementary bio-molecules bound to those master bio-molecules. Opposing electrical charges applied to electrodes located close to the non-confronting surfaces of the master and replica substrates, result equalizing electric charges accumulating on the confronting surfaces. The complementary bio-molecules are un-bound from the master bio-molecules by heating, and the electrodes shorted out so that the opposing electrical charges cancel. The equalizing electric charges, however, remain for a while on the inner, confronting surfaces and now provide an electric field in the separating, liquid layer. The freed, complementary bio-molecules have a natural charge and are, therefore, moved toward the replica substrate by this electric field.
|
