| 摘要 |
Disclosed are N-alkyl- N-acyl derivatives of the antibiotic thienamycin having the following structural formula: <IMAGE> wherein R1 is, inter alia, alkyl, alkenyl, aryl or aralkyl; and R2 is acyl. Such compounds, including their O- and carboxyl derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated. |
