COPOLYMERS BASED ON N-SUBSTITUTED ACRYLAMIDES, N-SUBSTITUTED METHACRYLAMIDES AND N,N. BSTITUTED ACRYLAMIDES AND THE METHOD OF THEIR MANUFACTURE

摘要

Copolymers consisting of (a) 39.9 to 99.9 molar percent of units of the general formula A, formed by a basic monomer selected among N-substituted acrylamideo, N-substituted methacrylamides and N, N-disubstituted acrylamides, (A) where R1 is H or CH3, R2 is an alkyl or alkoxyalkyl radical having from one to six carbon atoms and substituted or not with up to three OH groups, and R3 is H or R2 when R1 is H, or R3 is H when R1 is CH3; (b) 0.1 to 50 molar percent of units X formed by copolymerization with a monomer selected from the group comprising: , wherein R4 is hydrogen or methyl, R5 is a residue of p-nitro-phenol, 2,3,5-trichlorophenol, 8-hydroxyquinoline, N-hydroxy-succinimide or N-hydroxyphthalimide, and n = 0 to 4, , where in x = 2 to 10, , and , wherein the substituents R4 and R5 have the aforesaid meanings; and (c) 0 to 60 molar percent of units Z formed by copolymerization with a divinyl compound selected from the group comprising bis-acrylamides, bismethacrylamides, bis-acrylates, ethylene glycol dimethacrylate, diethylene glycol dimethacrylate, 1,4cyclohexyldimethyl dimethacrylate, 1,6-hexamethylene-bis-acryla-mide, 1,6-hexamethylene dimethacrylate, N,N-methylene-bis-acryla-mide, N,N-ethylene-bis-methacrylamide, tetraethylene glycol discrylate, tetraethylene glycol dimethacrylate, tetramethylene discrylate, 1,1,1-trimethylolethane trimethacrylate, 1,1,1-trime-thylolpropane triacrylate, 1,1,1-trimethylolpropane trimethacrylate, diisopropylene glycol dimethacrylate, ethylidene diacrylate, ethylidene dimethacrylate, divinylsulfone and triacryloylperhydrotriazine. These copolymers an particularly useful for the bonding of biologically active compounds. Copolymers containing the divinyl component (c) are suitable for use as separation membranes or as packings for columns for the gel or affinity chromatography.