| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to medicine and consists in a method of producing a drug preparation, method comprising formation of oil-in-water emulsion containing water, phospholipid, oil and vancomycin and/or gentamycin; homogenisation; microfluidisation; provision of pH from 3 to 6; lactoferrin for preparing dry paste; addition of ethanol or isopropanol in an amount of 25 wt% or more of weight of obtained solution; removal of ethanol or isopropanol for producing drug preparation containing from 1 to 20 wt% ethanol or isopropanol with respect to weight of depot preparation and sterilisation. Drug preparation contains not more than 4 wt% of water and is intended for administering intracutaneously, subcutaneously, intramuscularly through an incision or locally. Invention also relates to depot preparations containing vancomycin and/or gentamycin, and methods of administration thereof.EFFECT: technical result consists in storage stability, possibility of administering subcutaneously, intramuscularly or placement into wound, as well as more prolonged release of active agent.46 cl, 13 ex, 11 tbl, 14 dwg |
