发明名称 |
CHENODEOXYCHOLIC ACID |
摘要 |
<p>A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions to obtain a mixture of bile acids; isolating the bile acids from the remaining constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxycholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, purifying the chenodeoxycholic acid. The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.</p> |
申请公布号 |
CA1041479(A) |
申请公布日期 |
1978.10.31 |
申请号 |
CA19750234164 |
申请日期 |
1975.08.25 |
申请人 |
CANADA PACKERS LIMITED |
发明人 |
ZIEGLER, PETER;ATTWELL, MICHAEL C.;MASSIAH, THOMAS F.;VERGOTTINI, ROBERTO A. |
分类号 |
C07J9/00;(IPC1-7):07J9/00 |
主分类号 |
C07J9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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