发明名称 |
PROCESS FOR THE PREPARATION OF BENZODIAZEPINE DERIVATIVES |
摘要 |
<p>TRICYCLIC BENZODIAZEPINES Tricyclic benzodiazepine derivatives ("A") bearing a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.</p> |
申请公布号 |
CA1041499(A) |
申请公布日期 |
1978.10.31 |
申请号 |
CA19710109681 |
申请日期 |
1971.04.06 |
申请人 |
HOFFMANN-LA ROCHE LIMITED |
发明人 |
DERIEG, MICHAEL E.;EARLEY, JAMES V.;FRYER, RODNEY I.;STERNBACH, LEO H. |
分类号 |
C07D498/04;(IPC1-7):07D498/08 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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