| 摘要 |
PURPOSE:To obtain the title composition having excellent stability to shaking by blending elcatonin with a specific amount of a monocarboxy compound and adjusting pH and ionic strength to specific ranges. CONSTITUTION:An aqueous solution composition comprising elcatonin: 1-butyric acid-7-(L-2-aminobutyric acid)-26-aspartic acid-27-L-valine-29-L-alanine calcitonin (salmon) as an active ingredient is blended with a monocarboxy compound (e.g. acetic acid, lactic acid or L-histidine) having 0.05-20 millimol, preferably 0.1-5 millimol mol concentration and/or a water soluble salt thereof and adjusted to pH 5.0-6.5 and 0.01-0.5, preferably 0.04-0.3 ionic strength to give an aqueous solution composition. An effective amount of elcatonin is dissolved in an aqueous medium whose pH is adjusted by a buffer solution containing a monocarboxy compound and/or a water-soluble salt thereof and whose ionic strength is regulat ed by optionally adding a nontoxic strong electrolyte to prepare the aimed composition.
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