发明名称 |
Pharmaceutical composition containing 2-dimethylamino-6-diethyleneimidophosphamido-7-methyl-purine |
摘要 |
2-Dimethylamino-6-diethyleneimidophosphamido-7-methylpurine having the formula <IMAGE> A method for preparing 2-dimethylamino-6-diethyleneimido-phosphamido-7-methylpurine consisting of treating theo-bromine with heating to the boiling point and subsequently with phosphorus oxychloride and phosphorus pentachloride. The prepared 2,6-dichloro-7-methylpurine is heated to 50 DEG - 60 DEG C in an aqueous solution of ammonia and the resulting 2-chloro-6-amino-7-methylpurine is reacted, with heating, with a aqueous solution of dimethylamine. The obtained 2-dimethylamino-6-amino-7-methylpurine is reacted, at the boiling point, with either phosphorus oxychloride, or phosphorus pentachloride and formic acid. The resulting 2-dimethylamino-7-methylpurinyl-6-aminophosphoric dichloroanhydride is then treated with ethyleneimine in a medium of an organic solvent in the presence of an acceptor of hydrogen chloride, and the final product is then isolated.
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申请公布号 |
US4122173(A) |
申请公布日期 |
1978.10.24 |
申请号 |
US19760745547 |
申请日期 |
1976.11.29 |
申请人 |
GOLOVCHINSKAYA, ELENA SEMENOVNA;CHERNOV, VLADIMIR ALEXANDROVICH;CHAMAN, ELENA SILVESTROVNA;NIKOLAEVA, LJUDMILA ALEXANDROVNA;KORSUNSKY, VYACHESLAV SERGEEVICH |
发明人 |
GOLOVCHINSKAYA, ELENA SEMENOVNA;CHERNOV, VLADIMIR ALEXANDROVICH;CHAMAN, ELENA SILVESTROVNA;NIKOLAEVA, LJUDMILA ALEXANDROVNA;KORSUNSKY, VYACHESLAV SERGEEVICH |
分类号 |
C07D473/16;C07D473/40;C07F9/6561;(IPC1-7):A61K31/67 |
主分类号 |
C07D473/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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