EXTENDED CHAIN DERIVATIVES OF SOMATOSTATIN AND PROCESS THEREFOR

摘要

EXTENDED CHAIN DERIVATIVES OF SOMATOSTATIN AND PROCESS THEREFOR Compounds of the formula I or Ia (I) R1-Gly-Gly-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-NH?HCH2SH (Ia) wherein R1 is H-, H-Gly or H-Leu and R2 is H or COOH and pharmaceutically acceptable salts thereof, are disclosed. The compounds of formulae I and Ia are useful for the management of diabetes and the treatment of scromegaly. Methods for their use are also disclosed.