6,7-BENZOMORPHAN DERIVATIVES AND THEIR PRODUCTION

摘要

NOVEL 6,7-BENZOMORPHAN DERIVATIVES AND THEIR PRODUCTION A novel 2-substituted-6,7-benzomorphan derivative of the formula: and its pharmaceutically accpetable acid addition salts, which are useful as non-addicting analgesics and antitussives and can be prepared, for example, by reacting a 2-unsubstituted-6,7-benzomorphan derivative of the formula: with the reactive derivative of an alcohol of the formula: A'-Q , optionally followed by elimination of the protective group in the resulting product ¢wherein R1 is hydrogen, lower alkyl or C2-C6 alkanoyl; R2 and R3 are each lower alkyl and; A is lower alkyl, cyano(lower)alkyl, a benzoyl(lower)alkyl group, or substituted benzoyl(lower)alkyl, a phenyl(lower)alkyl group, a lower alkenyl group or a cyclo(lower)alkyl(lower)alkyl group; and A' is a group as mentioned in A or a substituted or unsubstituted benzoyl(lower)alkyl of which the carbonyl group is protected in the form of a ketal!.