Labile quaternary ammonium salts useful in binding bile acids in warm-blooded animals

摘要

Free and conjugated bile acids are effectively bound in warm-blooded animals by administering thereto, a therapeutically effective bile acid binding amount of a quaternary ammonium compound having the formula: (I) wherein >N represents a tertiary open chain or cyclic aliphatic amine; wherein >N represents an unsaturated amine; wherein R represents a member selected from the group consisting of a hydrogen atom, a C1-C20 open chain or cyclo alkyl group, a C1-C20 alkoxyalkyl group, a C1-C20 alkanoyloxyalkyl group, a C1-C20 haloalkyl group, a C1-C20 carboxyalkyl group, an aryl group, and a substituted aryl group, whose substituents are selected from the group consisting of a halogen atom, an O-C1-C4 alkyl group, an O-C1-C8 alkanoyl group, a nitro group, a carboxyl group, and a carboethoxy group; wherein R1, which may be the same or different, represents any member defined by R above with the proviso that R cannot be a hydrogen atom, a WHEREIN R3, R4, R5 and R6 are each selected from the group consisting of a hydrogen atom, a methyl group or an ethyl group, a C0-C22 straight or branched WHEREIN N IN EACH OCCURRENCE AND M REPRESENT AN INTEGER OF FROM 0 TO 22, AN WHEREIN A represents a C0-C22 straight or branched alkyl group as above or a -(CH2CH2O)p group, wherein the p represents an integer of from 0 to 22, and the residue of any naturally occurring bile acid or synthetic derivative thereof; and wherein X- represents a halogen atom or any other organic or inorganic monovalent anion are disclosed.