AMIDINOUREAS

摘要

1514198 Substituted phenyl guanidines WILLIAM H RORER Inc 30 May 1975 23574/75 Addition to 1451478 Heading C2C Novel compounds of Formula IA (wherein X1, Y1 and Z1 may be at any available position in the phenyl nucleus; X1 is a hydrogen or halogen atom; Y1 is a hydrogen or halogen atom, or is a lower alkyl haloloweralkyl, loweralkoxy or nitro group; either Z1 is a haloloweralkyl, haloloweralkoxy or loweralkylsulphonyl group, or-with the proviso that X1 and Y1 are not both hydrogen-Z1 is a halogen atom or a loweralkyl, loweralkoxy, nitro or cyano group; R is a loweralkyl group; R111 is a hydrogen atom or a loweralkyl, intermediate alkyl, cycloalkyl, cycloalkylloweralkyl, aralkyl, loweralkenyl, cycloalkenyl, aryl, acyl or aroyl group; and either R1 and R11, which may be the same or different, are each a hydrogen atom or a loweralkyl, intermediate alkyl, cycloalkyl, cycloalkylloweralkyl, aralkyl, loweralkenyl, cycloalkenyl, aryl, acyl or aroyl group, or R1 and R11 together are a loweralkylidenyl or heteroloweralkylidenyl group), and non-toxic acid addition salts thereof are prepared by standard methods. Pharmaceutical compositions in conventional forms having anti-hypertensive activity comprise an above novel compound and a carrier or diluent.