摘要 |
Water-soluble, substantially anhydrous materials such as anhydrous aspirin salt and anhydrous calcium aspirin salt, stable to hydrolysis, are prepared by subjecting a freeze-dried water-soluble material containing molecularly bound water which is susceptible to hydrolysis to a vacuum of 10 microns or less Hg to remove the molecularly bound water and condensing the removed water on a condenser below -50 DEG C.
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