发明名称 |
Heterocyclic-methylthioalkyl-amidines |
摘要 |
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkyl-isothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N''-methylguanidine. The compounds of this invention are histamine H2-antagonists.
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申请公布号 |
US4118496(A) |
申请公布日期 |
1978.10.03 |
申请号 |
US19770794177 |
申请日期 |
1977.05.05 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LIMITED |
发明人 |
DURANT, GRAHAM JOHN;GANELLIN, CHARON ROBIN;YOUNG, RODNEY CHRISTOPHER |
分类号 |
A61K31/33;C07D249/08;C07D261/14;C07D275/02;C07D277/26;C07D277/48;C07D285/12;(IPC1-7):A61K31/44;C07D213/58 |
主分类号 |
A61K31/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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