HUMAN PROINSULIN C-PEPTIDE DERIVATIVES

摘要

This invention discloses novel human C-peptide derivatives, namely tyrosylated human C-peptide derivatives and radioactive iodinated derivatives. These substances are exceptionally useful for the radioimmunoassay of human C-peptide or proinsulin in serum. The substances are represented by Arg-Arg-Steiner's C-peptide-Lys-Arg which is known as proinsulin 31-65 or C-peptide (35) and includes the two derivatives, tyrosylated C-peptide (35) and the radioiodinated compound thereof. The invention further discloses a method for their synthesis. These derivatives are very useful in immunoassay and the antibody produced by C-peptide (35) may be diluted up to 10,000 times while still producing useful results.