USE OF SIGMA LIGANDS WITH INDUCED OPIOIDS HYPERALGESIA

摘要

FIELD: chemistry.SUBSTANCE: group of inventions relates to use of sigma-receptor ligand, which is 4-{2-[5-methyl-1-(naphthalene-2-yl)-1H-pyrazole-3-yloxy]ethyl}morpholine or its salt for prevention and/or treatment of induced opioids hyperalgesia (OIH) associated with opioid therapy; use of its combination with opioid or opiatnym joint along same purpose; to use thereof for preparing drug for preventing and/or treating OIH associated with opioid therapy; to method of corresponding treatment.EFFECT: technical result consists in prevention of OIH developing while maintaining dose of opioid.8 cl, 16 dwg, 1 tbl