POLYPEPTIDE UND DEREN HERSTELLUNG

摘要

Snythetic analogs of beta -endorphin having the sequence beta -endorphin-(1-5)-(16-31) are disclosed. These compounds are potent opiate agonists and analgesic agents, having activities in excess of the parent compounds. Moreover, the present analogs lack the antigenic determinent site which is believed to reside in residues 6-15 of beta -endorphin. Thus the analogs present a substantially reduced risk of inducing an anaphylactic response in a treated individual.