| 摘要 |
<p>The present invention relates to methods and pharmaceutical preparations for the treatment of hypercholesterolaemia.It has now been found that, from amongst the wide variety of preparations, both in the nature of drugs and other products, which have hitherto been employed for the reduction of blood-cholesterol levels, it is possible to select combinations which exhibit a quite unexpectedly enhanced or synergistic effect, The combination needed to attain these remarkable results is formed by the administration Per os in a certain ratio (if appropriate separately but for convenience preferably in admixture) of botha) a hypocholesterolaemic compound of the general formula I: (I) in which R1 and R2, which may be the same or different, are each a hydrogen atom or a substituted or unsubstituted alkyl, alkoxy, or phenoxy group, R3 is a substituted or unsubstituted phenyl group and X is hydrogen (2 H) or oxygen, or an ingestible, non-toxic functional derivative of such compound, andb) an ingestible non-toxic metallic compound, capable of dissolution in the gastro-intestinal juices to yield a metallic salt or ion that can react with bile acids to form an insoluble or poorly soluble metal salt of these bile acids.</p> |
