| 摘要 |
<p>METHOD AND COMPOSITIONS FOR LOWERING INTRAOCULAR PRESSURE Intraocular pressure is lowered in mammals by derivatives of 21-amino-3.beta.-hydroxy-14.beta.,21-oxido-20-nor-5.beta.,14.beta.-cholan-23-oic acid lactam or 3.beta.,14,23-trihydroxy-24-nor-5.beta.,14.beta.-chol-20(22)-en-21-oic acid .gamma.-lactone in which the hydrogen of the 3.beta.-hydroxyl is replaced with lower alkanoyl, hexosyl, HOCO(CH2)nCO- wherein n is an integer from one to three, y+?OCO(CH2)nCO- wherein Y+ is a pharmaceutically acceptable cation and n is an integer from one to three, R3N+ OSO2wherein R3 is lower alkyl, or alanyl or a pharmaceutically acceptable acid addition salt thereof. Ophthalmic composition in which these derivatives are the active ingredient also are disclosed.</p> |
