| 摘要 |
Amidated immunoglobulins suitable for intravenous administration are prepared by reacting immunoglobulins with a molar excess of a primary monoamine and a carbodiimide or its salt in weakly acidic to neutral aqueous solution. As a result of the amidation, the undesired complement binding by the immunoglobulins is prevented or at least substantially decreased without the antibody action of the immunoglobulins being impaired. The process can be applied to reduced immunoglobulins, in which at least one disulphide bond has been converted to two sulphydryl bonds. |
