| 摘要 |
A thienamycin-containing fermentation broth or solution is brought into contact with a liquid ion exchanger which is dissolved in an organic solvent and is insoluble in water. In this process, the antibiotic is transferred, by forward extraction, into the liquid ion exchanger system. The liquid ion exchanger system, containing the antibiotic, is then brought into contact with an aqueous buffer. During this process, the antibiotic is transferred, by back extraction, into the aqueous buffer phase. The process is simple to carry out and the antibiotic thienamycin accrues, as the end product, in high yield and in pure form. Thienamycin exhibits antibiotic activity against Gram-negative and Gram-positive microorganisms. |
