ANTI-INFLAMMATORY (HOLO-4-BIPHENYLYL)-ALKANOLAMINES

摘要

Compounds of the formula R-A-Z wherein R is a 4-biphenylyl or 4-phenoxyphenyl or a corresponding group monosubstituted or polysubstituted by one or more of F, Cl, and Br; A is -CH(CH3)-CH2-(CH2)n-, -C(CH3)=CH-(CH2)n- or -C(OH)(CH3)-CH2-(CH2)n-, Z is -NR1R2, imidazol-1-yl, phthalimido or 4,5-dihydro-4-oxophthalazin-1-yl-amino; R1 and R2 each are H or alkyl, azaalkyl or acyl, each of 1-6 carbon atoms or collectively are alkylene of 4-7 carbon atoms, 3-oxapentamethylene or 3-R3-3-azapentamethylene; R3 is H or alkyl or hydroxyalkyl each of up to 6 carbon atoms; and n is 0, 1, or 2, and their physiologically acceptable acid addition salts possess anti-inflammatory, anti-arteriosclerotic and serum cholesterol and trigylyceride level lowering activities.