| 摘要 |
Preventive as well as therapeutic treatment to alleviate the symptoms of diseases characterized by defects in keratinization consisting of the topical application of a solution, lotion, cream or shampoo containing one or more of the alpha -hydroxy or alpha -keto acid amides and/or ammonium salts is disclosed. The compounds include amide and/or ammonium salt forms of citric acid, glycolic acid, glucuronic acid, galacturonic acid, glucuronolactone, gluconolactone, alpha -hydroxybutyric acid, alpha -hydroxyisobutyric acid, malic acid, mandelic acid, pyruvic acid, beta -phenyllactic acid, beta -phenylpyruvic acid, saccharic acid, tartaric acid, tartronic acid and beta -hydroxybutyric acid. The therapeutic composition may include one or more of the compounds present in a total amount of from 1 to 20 percent. Topical application to affected areas has been found to achieve from a substantial to a complete remission of dandruff and acne.
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