发明名称 |
Process for preparing 2,4-dihaloquinazolines |
摘要 |
A one-step process for the preparation of 2,4-dihaloquinazolines is disclosed beginning with methoxycarbonyl- or phenoxycarbonyl-derivatives of substituted phenylureas which are cyclized and concomitantly halogenated with a cyclizing-halogenating reagent such as N,N-dimethylaniline in phosphorus oxychloride. The 2,4-dihaloquinazolines of the instant process are particularly valuable as intermediates in the preparation of 4-amino-2-(4-substituted-piperazin-1-yl) quinazolines useful in the treatment of cardiovascular disorders such as hypertension.
|
申请公布号 |
US4102885(A) |
申请公布日期 |
1978.07.25 |
申请号 |
US19770807938 |
申请日期 |
1977.06.20 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
CRENSHAW, RONNIE RAY;LUKE, GEORGE MICHAEL;PARTYKA, RICHARD ANTHONY |
分类号 |
C07C273/18;C07D239/95;(IPC1-7):C07D239/95 |
主分类号 |
C07C273/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|