Novel cyclopropylmethylamine derivatives

摘要

Novel cyclopropylmethylamine compounds of the formula: <IMAGE> wherein Ar1 represents a phenyl group having one or more substituents selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy and trifluoromethyl, of which at least one is present at the o- or m-position, Ar2 represents an unsubstituted phenyl group or a phenyl group substituted with one or more substituents selected from the group consisting of halogen and C1-C4 alkyl, R represents hydrogen, C1-C4 alkyl or C2-C4 hydroxyalkyl and R' represents C1-C4 alkyl or C2-C4 hydroxyalkyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reduction of the corresponding compounds of the formula: <IMAGE> wherein Ar1, Ar2, R and R' are each as defined above or by condensation of the corresponding compounds of the formula: <IMAGE> wherein Ar1 and Ar2 are each as defined above and X is a conventional leaving (removable) group with amines of the formula: <IMAGE> wherein R and R' are each as defined above.