WERKWIJZE VOOR HET BEREIDEN VAN BASISCH GESUB- STITUEERDE ALKYLTHEOFYLLINEDERIVATEN.

摘要

Basic substituted alkyl theophylline derivatives of the formula (I) in which Alk is a straight or branched chain alkylene group with 2 to 4 carbon atoms and R is hydrogen or a methyl group are produced by catalytic hydrogenation of compounds of the formula (II) where the phenolic hydroxyl groups and/or the secondary basic nitrogen atom can contain protective groups using as the solvent a compound of the formula (III) where R', R'' and R''' are the same or different and are alkyl groups of 1 to 2 carbon atoms and R' together with R''' can also be an alkylene bridge with 3 to 4 carbon atoms and in a given case the protective groups present are split off.