| 摘要 |
<p>A process for the preparation of 5-aminonaphthostyril of the general formula <IMAGE> where R = H or C1-C4-alkyl, R' = H, C1-C4-alkyl, cycloalkyl, arylakyl, C1-C4-cyanoalkyl or C1-C4-hydroxyalkyl and R'' = R' but cannot be H, and R' and R'' together can form an optionally substituted ring which may or may not contain other heteroatoms, is characterised in that a direct amination of naphthostyril with N-chloramine is carried out in a system of the redox type in an acid reaction medium with a strong acid. Such a procedure makes it possible to obtain a general, eminently industrial method for the direct amination of naphthostyril and in particular via the alkylamination of the said substrates, without the need for complicated operations and successive reaction stages as compared with the processes of the known state of the art. Such compounds are in particular used in the field of fine chemicals and above all as intermediates in the field of dyes and pharmaceutical products.</p> |
