Alkyl-acyloxy stearate deriv. prepn. - by transesterifying a tri:glyceride and acylating with an acid anhydride

摘要

Alkayl acyloxystearates of formula CH3.(CH2)n.CHO(O-COR1) -(CH2)15n COOR (I) (where R is 6-15C alkyl; R1 is 1-3C alkyl; n is 5-8) are prepd. by transesterification of a triglyceride of formula (II) with an alcohol ROH and acylation of the prod. using an acid anhydride of formula R1-CO-O-CO-R1. Used as solvents and protecting agents for antibiotics, vitamins etc. They are also useful in dermatology to replace perhydrosqualene oils. A typical prod. is 2'-ethyl hexyl 12-acetoxy stearate, prepd. by transesterifying hydrogenated castor oil with 2-ethyl hexanol using stearyl titanate as catalyst.