发明名称 |
PROCESS FOR PREPARATION OF ABIETAMIDE DERIVATIVES |
摘要 |
<p>A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula: HNRR' wherein R and R' are each hydrogen, a straight chain or branched alkyl group having 3 to 15 carbon atoms, a lower alkenyl group, a cycloalkyl group, a phenyl group, a phenylalkyl group and a phenylalkyl group having a lower alkyl group at the alpha -position, with the proviso that such amines where both R and R' are hydrogen or where one of R and R' is hydrogen and the other is phenyl are excluded. The invention further comprises the resulting abietamide derivative reaction products, compositions containing effective blood serum cholesterol-reducing amounts of said abietamide derivatives and their use as anti-arteriosclerotic agents.</p> |
申请公布号 |
CA1034594(A) |
申请公布日期 |
1978.07.11 |
申请号 |
CA19750227171 |
申请日期 |
1975.05.16 |
申请人 |
NIPPON SHINYAKU CO., LTD. |
发明人 |
MURAI, HIROMU;OHATA, KATSUYA;ENOMOTO, HIROSHI;SEMPUKU, KENJI;KITAGUCHI, KOJI;FUJITA, YUKIO;YOSHIKUNI, YOSHIAKI;KURA, KOHEI;SAITO, KATSUHIDE;MORI, TAMIKI;YASUTOMI, YASUO |
分类号 |
A61K31/16;A61K31/165;C07C67/00;C07C231/00;C07C231/02;C07C233/00;C07C233/38;C07C233/58 |
主分类号 |
A61K31/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|