DERIVATIVE OF INDANE CARBOXYLIC ACID

摘要

The preparation of the carboxylic acids derived from indane represented by the formula: in which R has the meaning given in Claim 1, in the free form, of their therapeutically acceptable salts, and of certain of their amino esters and carboxamides are described. Indane which is free of substituent on the benzene ring but which carries a -COO(lower alkyl) group in place of the -COOH group is reacted with a halide R-C(O)-hal according to the Friedel-Crafts reaction, and the ester group of the intermediate compound obtained is saponified. The final product can be converted to its amino ester and dialkylaminoalkylcarboxamide by standard reactions. Substituents can also be introduced into the group R = phenyl. The compounds of formula I and their described derivatives are antiinflammatory, analgesic and platelet antiaggregating medicaments.