| 摘要 |
To prepare alpha -L-aspartyl-L-phenylalanine methyl ester, alpha -L-aspartyl-L-phenylalanine is brought into contact with a reaction medium. 100 g of reaction medium contain a) 0.1 to 0.8 mol of at least one hydrogen halide, b) 0.1 to 1.1 mol of methanol, and c) water as the remainder. 1.0 to 20.0 mol of hydrogen halide and at least 1.0 mol of methanol must be present in the medium per mole of alpha -L-aspartyl-L-phenylalanine. A solid hydrogen halide salt of alpha -L-aspartyl-L-phenylalanine methyl ester is formed. The solid salt is separated off and converted into alpha -L-aspartyl-L-phenylalanine methyl ester ( alpha -APM). alpha -APM is suitable for use as a sweetener. |
