PROCESS FOR PRODUCING SUBSTITUTED BENZAMIDE DERIVATIVES

摘要

1500105 Benzamides SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE 8 June 1976 [10 June 1975] 23695/76 Heading C2C Novel compounds (I) (including salts and oxides thereof) in which A is a hydrogen atom or a C 1-5 alkyl or 6 2-5 alkenyl group; X is a hydrogen atom or a C 1-5 alkoxy, C 1-5 alkyl, C 2-5 alkenyloxy or C 2-5 alkenyl group; Y is a hydrogen or halogen atom or a nitro, C 1-5 alkyl, C 1-5 alkoxy, amino or substituted amino group; Z is a hydrogen or halogen atom, a C 1-5 alkoxy or C 1-5 alkylsulphonyl group or a group of formula SO 2 NR 1 R 2 in which each of R 1 and R 2 , which may be the same or different, is a hydrogen atom or a C 1-5 alkyl group, or -NR 1 R 2 is a heterocyclic ring optionally containing another hetero atom; W is a C 1-4 straight or branched-chain alkylene group; B is a group of formula NR 3 R 4 in which R 3 is a C 1-5 alkyl group and R 4 is a C 1-5 hydroxyalkyl group; or B is a nitrogen-attached heterocyclic ring optionally containing a second nitrogen and optionally having a substituent; or B is a racemic, dextrorotary or laevorotary heterocyclic radical of Formula (IV) in which R is a C 1-5 alkyl group containing a reactive function and m is 1, 2 or 3, including the dextrorotatory and laevorotatory forms of the compounds, are made by interacting H 2 N-W-B and appropriate benzoic acids or derivatives thereof. Pharmaceutical preparations having antiemetic action contain (I) as active ingredient. Administration is parenterally.