发明名称 |
{66 {HU 9 (11){B -5{60 -D-homo-20-keto steroids |
摘要 |
3 alpha -Hydroxy and 3 alpha -acyloxy- DELTA 9(11)-5 alpha -D-homo-20-ketopregnenes of the formula <IMAGE> wherein R is hydrogen or acyl, R1 is hydrogen or methyl and R2 is methyl or ethyl, are produced by esterifying a corresponding 3 beta -hydroxy-5 alpha -20-keto pregnane of the formula <IMAGE> wherein R1 and R2 have the values given above, with m-iodo-benzoic acid with inversion of the 3 beta -oxy group to a 3 alpha -oxy group; chlorinating the thus-produced 3 alpha -m-iodobenzoyl ester with dichloroiodobenzene under irradiation; and treating the reaction product with a dehydrohalogenating silver salt. Optionally thereafter, the 3 alpha -iodobenzoyl group is split off in a conventional manner to produce the corresponding 3 alpha -hydroxy steroid and optionally the thus-produced 3 alpha -hydroxy steroid is esterified to produce a desired 3-ester thereof.
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申请公布号 |
US4097678(A) |
申请公布日期 |
1978.06.27 |
申请号 |
US19760693847 |
申请日期 |
1976.06.08 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
KERB, ULRICH;WIECHERT, RUDOLF;ENGELFRIED, OTTO |
分类号 |
C07J63/00;(IPC1-7):C07J63/00 |
主分类号 |
C07J63/00 |
代理机构 |
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代理人 |
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地址 |
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