1,2,3,4-TETRAHYDRO-4-OXO(OROXY)-1-NAPHTHYLUREA DERIVATIVES,VETERINARY COMPOSITIONS CONTAINING THEM AND THE 1,2,3,4 TETRAHYDRO-4-OXO-1-NAPHTHYLAMINE PRECURSORS

摘要

Tetrahydronaphthylureas of formula (I), their racemic mixture, cis and trans isomers and when U = CHOR6 their optical isomers, are novel cpds. (where X = O or S; U = R1,R2 independently = H or 1-4C alkyl; R3 = H, 1-4C alkyl, 3-5C alkynyl, 3-5C alkenyl, 1-4C alkoxy, benzyl or benzyloxy; R4 = H, 1-4C alkyl or 1-4C alkoxy; R5 = H or 1-4C alkyl; R6 = H, 1-4C alkyl or 1-4C acyl. The cpds. are useful as animal growth promoters which may be administered with feed at levels of 0.001-0.08 wt. % (pref. 0.001-0.04 wt. %), as implants which release daily 0.0005-0.5 mg/kg (pref. 0.001-0.2 mg/kg) or by sub-cutaneous or intramuscular injection. The (S) isomers generally have superior activity to the (R) isomers.