| 摘要 |
1514219 Moenomycin preparation HOECHST AG 21 July 1975 [23 July 1974] 30393/75 Heading C2A A process for the preparation of moenomycin comprises fermenting a moenomycin-forming Streptomyces in the presence of a fat and a non-ionogenic surfactant of the general formula wherein R represents a saturated or monounsaturated hydrocarbon radical having from 8 to 18 carbon atoms, which may be substituted by a hydroxyl group provided it is not bound to a carbon atom carrying a double bond and not bound to a carbon atom directly bound to the oxygen atom, and n is from 18 to 30. The surfactant suitably has a molecular weight of from 1000 to 1500, a turbidity point of 73 to 79, an hydroxyl number of 39 to 78, and a hydrophilic-lipophilic balance value of 16 to 18. The moenomycin-forming streptomyces comprises Streptomyces ghansensis ATCC 14,672, Streptomyces bambergiensis ATCC 13,879, Streptomyces ederensis ATCC 15,304 or Streptomyces geysiriensis ATCC 15,303 or a mutant or revertant thereof.
|
