PREPARATION OF DRY CRYSTAL OF ALPHA-L-ASPARTYL-L-PHENYLALA-NINE METHYL ESTER HAVING IMPROVED SOLUBILITY

摘要

PURPOSE:To industrially readily provide the subject crystal of IB type having good solubility by continuously air-drying the wet crystal of alpha-L-aspartyl-L- phenylalanine methyl ester having a specific water content with hot air having a specific temperature. CONSTITUTION:alpha-L-Aspartyl-L-phenylalanine methyl ester (hereinafter referred to as aspartame) having a water content of <=50wt.% is dried with hot air of 80-120 deg.C, preferably 130-160 deg.C, to a water content of 2-6wt.% to provide the objective crystal. It is preferable to prepare the aspartame wet crystal as the raw material by a stationary crystallization method, since the objective crystal is effectively prepared because the crystal having a water content of 20-50wt.% is obtained only by the centrifugal separation of the crystal after the crystallization.