发明名称 |
Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals |
摘要 |
A complex of a chelating agent is formed and labelled with technetium-99m. The chelating agent is either an ethylenediamine carboxylic acid or its salt having a phenolic group at each end of the molecule such as EDDHA and HBED or alternatively the phenolic amino carboxylic acid or its salt having a single phenolate group such as HBG or HBS. The complex is a stannous complex which when labelled with technetium-99m has a good balance of lipo-solubility and waater-solubility to permit hepato-biliary imaging. The radiopharmaceutical may be useful for assessing hepatobiliary function in animals including human beings. A particularly useful chelating agent is ethylene-bis-( alpha -imino-2-hydroxy-5-bromophenyl acetic acid).
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申请公布号 |
US4091088(A) |
申请公布日期 |
1978.05.23 |
申请号 |
US19760728099 |
申请日期 |
1976.09.30 |
申请人 |
AUSTRALIAN ATOMIC ENERGY COMMISSION |
发明人 |
HUNT, FREDERICK CHARLES;WILSON, JOHN GERALD |
分类号 |
A61K51/04;(IPC1-7):A61K27/00;A61K43/00 |
主分类号 |
A61K51/04 |
代理机构 |
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