| 摘要 |
1510841 11-Substituted testasterone ROYSSEL-UCLAF 4 July 1975 [4 July 1974] 28185/75 Heading C2U [Also in Division C3] The invention comprises compounds of formula wherein Y is -O-CO-(CH 2 ) n -CO 2 H or (where n is 1-18), with the exclusion of the 11α-hemisuccinate; and their preparation by reduction of the corresponding 17-ones, in which, in the case of the 11-hemiterephthalates, the carboxy group is protected by alkylation and the 3-oxo-#<SP>4</SP> grouping is protected by enol alkylation. Conjugates of compounds I with bovine serum albumin are prepared by the mixed anhydride method. Intermediates prepared are: 11#-(3-carboxypropionyloxy)androst - 4 - ene - 3,17 - dione; 11α- and 11# - [p - (methoxycarbonyl)benzoyloxy]androst - 4 - ene - 3,17 - dione; 11α- and 11# - [p - (methoxycarbonyl)benzoyloxy] - 3- ethoxyandrosta - 3,5 - diene - 17 - one; 11α- [p - (methoxycarbonyl)benzoyloxy] - 3 - ethoxyandrosta - 3,5 - diene - 17# - ol; 11α- [p- (methoxycarbonyl)benzoyloxy] - 17# - hydroxy. androst-4-en-3-one; and 11#-(p-carboxybenzoyloxy)-3-ethoxyandrosta-3,5-dien-17#-ol.
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