发明名称 OPHTHALMIC AND OTIC PREPARATIONS
摘要 <p>2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine, which is intended as a potentiator for sulphacetamide contained in a pharmaceutical preparation for administration to the eye or to the ear, which additionally contains polymixin in the form of a pharmaceutically acceptable salt, is prepared by reacting an appropriately substituted beta -aminoalpha -benzylacrylonitrile of the accompanying formula, in which Z denotes an aliphatic, aromatic or heterocyclic amino group -NR'R'', where R' or R'' can also denote hydrogen, with guanidine. <IMAGE></p>
申请公布号 CA1031263(A) 申请公布日期 1978.05.16
申请号 CA19740216920 申请日期 1974.12.24
申请人 WELLCOME FOUNDATION LIMITED (THE) 发明人 HOLSTIUS, ELVIN A.;ALVAN, GEORGE E.
分类号 A61K31/18;A61K9/00;A61K9/08;A61K31/505;A61K38/00;A61P31/12;C07D239/49 主分类号 A61K31/18
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