TEMPERING TISSUE FOR HEPARIN PRODUCTION

摘要

IMPROVED PROCESS FOR TEMPERING TISSUE FOR HEPARIN PRODUCTION An improved method of tempering frozen heparin-bearing animal tissue is disclosed wherein the frozen tissue is particulated, thawed and warmed in a heat exchanger and fermented at temperatures ranging from 45.degree.-95.degree.F. for 2 to 15 hours. Putrefaction and odor are avoided, the tissue has improved uniformity in biochemical content and is capable of high heparin yields when processed according to known procedures. When the tempered tissue is defatted with an azeotropic solvent, more of the fat is removed and the defatted tissue is more permeable to heparin recovery solutions and heparin isolation is facilitated.